Impact of loss of high-molecular-weight von Willebrand factor multimers on blood loss after aortic valve replacement
نویسندگان
چکیده
منابع مشابه
Impact of loss of high-molecular-weight von Willebrand factor multimers on blood loss after aortic valve replacement.
BACKGROUND Severe aortic stenosis is associated with loss of the largest von Willebrand factor (vWF) multimers, which could affect primary haemostasis. We hypothesized that the altered multimer structure with the loss of the largest multimers increases postoperative bleeding in patients undergoing aortic valve replacement. METHODS We prospectively included 60 subjects with severe aortic steno...
متن کاملRapid Restoration of Thrombus Formation and High-Molecular-Weight von Willebrand Factor Multimers in Patients with Severe Aortic Stenosis After Valve Replacement
AIM Patients with severe aortic stenosis (AS) may have bleeding episodes due to the loss of high-molecular-weight (HMW) von Willebrand factor multimers (VWFMs). The absence of HMW-VWFMs and bleeding tendency are usually corrected after aortic valve replacement (AVR). To investigate the process of VWFM recovery and symptoms in patients with severe AS, we analyzed changes in VWF antigen (VWF:Ag),...
متن کاملUpdate on von Willebrand factor multimers: focus on high-molecular-weight multimers and their role in hemostasis
Normal hemostasis requires von Willebrand factor (VWF) to support platelet adhesion and aggregation at sites of vascular injury. VWF is a multimeric glycoprotein built from identical subunits that contain binding sites for both platelet glycoprotein receptors and collagen. The adhesive activity of VWF depends on the size of its multimers, which range from 500 to over 10 000 kDa. There is good e...
متن کاملErratum to: Impact of energy loss index on left ventricular mass regression after aortic valve replacement
The original version of this article unfortunately contained errors. In the Methods section under the subheading ‘‘Echocardiography,’’ in the first paragraph, the 13th sentence, ‘‘The ELCo was calculated as [EOA AA]/(AA EOA) [12, 13, 18].’’ should be ‘‘The ELCo was calculated as [EOA 9 AA]/(AA EOA) [12, 13, 18].’’ In the Discussion section, in the fourth paragraph, the last sentence, ‘‘Theoreti...
متن کاملImpact of energy loss index on left ventricular mass regression after aortic valve replacement
BACKGROUND Recently, the energy loss index (ELI) has been proposed as a new functional index to assess the severity of aortic stenosis (AS). The aim of this study was to investigate the impact of the ELI on left ventricular mass (LVM) regression in patients after aortic valve replacement (AVR) with mechanical valves. METHODS A total of 30 patients with severe AS who underwent AVR with mechani...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2012
ISSN: 0007-0912
DOI: 10.1093/bja/aer512